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PARK Hyokeun 朴孝根
PhD, University of Illinois at Urbana-Champaign
Associate Professor
FULL CV | Personal Home Page
Tel 2358 7322
Fax 2358 1652
Email hkpark
Office Room 5452
Professor Hyokeun Park obtained his BA (2000) and MS (2002) degrees from the Seoul National University in Korea and his PhD (2006) degree from University of Illinois at Urbana-Champaign in the United States. He worked as a post-doctoral research associate at Stanford University. He joined the Department of Physics and Division of Life Science of HKUST in 2014.

Professor Park’s main research interests focus on the development of new single-molecule fluorescence imaging techniques and their application to address biological questions. In particular, he is interested in developing new fluorescence imaging techniques to measure the location accurately and observe the interaction between proteins simultaneously. He also investigates how the synaptic transmission and transport of vesicles and organelles are disrupted in neurodegenerative diseases such as Parkinson’s and Huntington’s diseases.
Research Areas
  • Single molecule biophysics of motor proteins
  • Real-time imaging in live cells
  • Mechanobiology of cancer cells
  • Developing new fluorescence microscopy techniques
  • Synaptic transmission in neurons
  • Real-time tracking of single vesicles in live neurons
  • Mechanism of neurodegeneration in Huntington's disease
Representative Publications
  • "Influence of synaptic vesicle position on release probability and exocytotic fusion mode", Hyokeun Park, Yulong Li, and Richard W. Tsien, Science 335, 1362-1366 (2012). Selected for F1000Prime.
  • "In vitro & in vivo FIONA and other acronyms for watching molecular motors walk", Paul R. Selvin, Tyler Lougheed, Mindy Tonks Hoffman, Hyokeun Park, Hamza Balci, Benjamine H. Blehm, and Erdal Toprak, Single Molecules: A Laboratory Manual, Cold Spring Harbor Press: New York, 37-71, (2008).
  • "Single-molecule fluorescence to study molecular motors", Hyokeun Park, Erdal Toprak, and Paul R. Selvin, Quarterly Review of Biophysics, 40, 87-111, (2007).
  • "How myosin VI coordinates its heads during processive movement", H. Lee Sweeney, Hyokeun Park, Alan B. Zong, Paul R. Selvin, and Steven S. Rosenfeld, EMBO J. 26, 2682-2692. (2007).
  • "The unique inset at the end of the myosin VI motor is the sole determinant of directionality", Hyokeun Park, Anna Li, Li-Qiong Chen, Anne Houdusse, Paul R. Selvin, and H. Lee Sweeney, PNAS USA, 104, 778-783 (2007).
  • "Full-length myosin VI dimerizes and moves processively along actin filaments upon monomerculstering", Hyokeun Park, Bugs Ramamurthy, Dan Safer, Mirko Travaglia, Li-Qiong Chen, Clara Franzini-Armstrong, Paul R. Selvin, and H. Lee Sweeney, Mol. Cell, 21, 331–336 (2006).
  • "Nanometer localization of single ReAsH molecules", Hyokeun Park, George Hanson, Steven Duff, and Paul R. Selvin, J Microsc, 216, 199-205 (2004).
  • "Myosin VI steps via a hand-over-hand mechanism with its lever arm undergoing fluctuations when attached to actin", Ahmet Yildiz*, Hyokeun Park*, Dan Safer, Zhaohui Yang, Li-Qiong Chen, Paul R.Selvin, and H. Lee Sweeney, J. Biol. Chem., 279, 37223-37226 (2004). (* - Equal contribution)
  • "Photoelectron Spectroscopy of s-Triazine Anion Clusters: Polarization-induced Electron Binding in Aza-aromatic Molecule", Jeong Hyun Kim, Jae Kyu Song, Hyokeun Park, Sang Hak Lee, Sang Yun Han, and Seong Keun Kim, J. Chem. Phys., 119, 4320-4327(2003).
Full Publication List [HKUST Scholarly Publications]